Type 1 Interferon Dynamics in Bacterial Infection
نویسندگان
چکیده
منابع مشابه
Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.
Defence mechanisms against intracellular bacterial pathogens are incompletely understood. Our study characterizes a type I IFN-dependent cell-autonomous defence pathway directed against Legionella pneumophila, an intracellular model organism and frequent cause of pneumonia. We show that macrophages infected with L. pneumophila produced IFNβ in a STING- and IRF3- dependent manner. Paracrine type...
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Human T-cell lymphotropic virus type-I (HTLV-I) was the first human retrovirus associated with malignancy. The prevalence of HTLV-I infection varies significantly in different regions of the world. In this study, the prevalence of HTLV-I infection among ethnic Jews living in Shiraz, South of Iran, was investigated. 286 blood samples were obtained. HTLV-1 antibody assay on serum samples was d...
متن کاملModelling dynamics of the type I interferon response to in vitro viral infection.
Innate immunity is crucial in the early stages of resistance to novel viral infection. The family of cytokines known as the interferons (IFNs) forms an essential component of this system: they are responsible for signalling that an infection is underway and for promoting an antiviral response in susceptible cells. We construct a spatial stochastic model, parameterized by experimental data and i...
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Antibacterial effect of known interferon inducers was investigated. Intraperitoneal injection of statolon or pyran markedly enhanced the survival of mice challenged with Klebsiella pneumoniae. The sparing effect of these two interferon inducers resembled that of bacterial endotoxin. Significant protection was obtained when the inducers were administered 24 hr before challenge. Treatments given ...
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ژورنال
عنوان ژورنال: Journal of Infectious Diseases & Travel Medicine
سال: 2018
ISSN: 2640-2653
DOI: 10.23880/jidtm-16000120